When looking at this memefied picture:

or at its variation:

I can't help asking myself: do people know the source of the image? Do they understand that it’s the gallbladder? That it's a part of this strip:
which, in turn, is related to this strip:
Do they understand the pathophysiology that this comic illustrates? Do they see the context?
I don't know why I keep wondering this. I guess it's slightly annoying that an image gets torn out of its context. I understand that this is probably how modern memes work, but still...