Andrey (azangru) wrote,
Andrey
azangru

There's something I don't understand about recombinant adenovirus vaccines (AZ, J&J, Sputnik).

They all seem to be using a simian adenovirus as a vector. The reason it's a simian rather than a human adenovirus is, as far as I understand, our pre-existing immunity to human adenoviruses, since we've been infected with them many times over the course of our lives. Whereas we have not been exposed to chimpanzee adenoviruses before, so our immune system is happily oblivious of their existence and will not attack them and prevent them from entering cells.

Fine. So does an injection of the vaccine count as an exposure of the immune system to this virus? Does the immune system learn about simian adenovirus antigens after a shot? Will it attack the virus itself during the second shot? What about the booster shot?
Subscribe

  • (no subject)

    Someone from JetBrains listing five soft skills: "Number one, communication. Number two, empathy. Number three, respect. Number four, integrity. And…

  • (no subject)

    On the scale of holy fucking shit, it's probably right up there next to Australia. Assuming it's true, of course. That second tweet about male…

  • (no subject)

    I was sure the Latin cunnus and the English cunt were related; but John McWhorter, in Nine Nasty Words, points out that they can't be. Because…

  • Post a new comment

    Error

    default userpic
    When you submit the form an invisible reCAPTCHA check will be performed.
    You must follow the Privacy Policy and Google Terms of use.
  • 0 comments